5-HT6 RECEPTORS POSITIVELY COUPLED TO ADENYLYL-CYCLASE IN STRIATAL NEURONS IN CULTURE

被引：106

作者：

SEBBEN, M ^{[1
]}

ANSANAY, H ^{[1
]}

BOCKAERT, J ^{[1
]}

DUMUIS, A ^{[1
]}

机构：

[1] CCIPE,CNRS,UPR 9023,F-34094 MONTPELLIER 5,FRANCE

来源：

NEUROREPORT | 1994年 / 5卷 / 18期

关键词：

5-HT6; RECEPTOR; INTRACELLULAR CAMP FORMATION; STRIATAL NEURONS IN CULTURE; I-125] LSD BINDING;

D O I：

10.1097/00001756-199412000-00037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

5-HT receptor positively coupled to adenylyl cyclase in striatal neurones in culture does not correspond to the 5-HT4 receptor. 5-HT induces an increase in cAMP level with an EC(50) of 125 nM. 5-HT agonists displayed the following rank order of potencies 5-HT > LSD > 5-MeOT > 5-CT. 8-OH-DPAT, RU 24969 and cisapride were inactive. The most efficacious antagonists were methiothepin and tricyclic antipsychotic drugs (clozapine, amitriptyline and nortryptyline). The pharmacological profile defined by both functional studies (cAMP level) and binding experiments ([I-125]-LSD binding), and its localization in striatal neurones are in favour of the presence of the recently cloned 5-HT6 receptor in these cells.

引用

页码：2553 / 2557

页数：5

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