CONCENTRATIONS OF AMYLOID-BETA PROTEIN IN CEREBROSPINAL-FLUID OF PATIENTS WITH ALZHEIMERS-DISEASE

被引：87

作者：

VANGOOL, WA

KUIPER, MA

WALSTRA, GJM

WOLTERS, EC

BOLHUIS, PA

机构：

[1] Department of Neurology, Academic Medical Center, University of Amsterdam

[2] Department of Neurology, Academisch Ziekenhuis der Vrije Universiteit, Amsterdam

来源：

ANNALS OF NEUROLOGY | 1995年 / 37卷 / 02期

关键词：

D O I：

10.1002/ana.410370221

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Deposition of fibrillar amyloid beta protein (A beta) is increased in brains of patients with Alzheimer's disease. Concentrations of A beta were measured in cerebrospinal fluid with an enzyme-linked immunosorbent assay in 10 neurological patients free from neurodegenerative disease, 28 patients with Parkinson's disease, and 18 patients with probable Alzheimer's disease. Levels of A beta in cerebrospinal fluid were not significantly different among these groups. This observation suggests that concentrations of soluble A beta in cerebrospinal fluid as measured in this study do not reflect the amount of fibrillar, aggregated A beta in the brain of patients with Alzheimer's disease.

引用

页码：277 / 279

页数：3

共 17 条

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