BIOLOGICAL-ACTIVITY OF D-BACLOFEN AND 1-BACLOFEN (LIORESAL)

被引：213

作者：

OLPE, HR ^{[1
]}

DEMIEVILLE, H ^{[1
]}

BALTZER, V ^{[1
]}

BENCZE, WL ^{[1
]}

KOELLA, WP ^{[1
]}

WOLF, P ^{[1
]}

HAAS, HL ^{[1
]}

机构：

[1] UNIV ZURICH,DEPT NEUROSURG,CH-8091 ZURICH,SWITZERLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1978年 / 52卷 / 01期

关键词：

Baclofen; Convulsion; Enantiome; Microiontophoresis; Reflex;

D O I：

10.1016/0014-2999(78)90032-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Racemic, d,1-baclofen, and l-baclofen depressed the patellar, flexor, linguo-mandibular (0.1-30 mg/kg i.v.) and the H-reflex (1-3 mg/kg i.v.) in a dose-dependent fashion. Racemic and l-baclofen partly antagonized electro-ionotrophoretically. d,l-baclofen and l-baclofen (0.1-3.0 mg/kg i.v.) moderately reduced the blood pressure in cats. Dextrorotatory baclofen, at identical doses was inactive in all these test. It is conlcuded that the biologica activity of baclofen resides with the l-enantiomer. © 1978.

引用

页码：133 / 136

页数：4

共 10 条

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