EFFECT OF DOPAMINERGIC MODIFIERS ON MORPHINE-INDUCED ANALGESIA AND RESPIRATORY DEPRESSION

被引：28

作者：

MCGILLIARD, KL ^{[1
]}

TAKEMORI, AE ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT PHARMACOL,MINNEAPOLIS,MN 55455

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 54卷 / 1-2期

关键词：

Analgesia; Dopaminergic antagonists; L-Dopa; Morphine; Respiratory depression;

D O I：

10.1016/0014-2999(79)90408-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influences of the dopaminergic system on morphine-induced analgesia and respiratory depression were compared using modulators of dopaminergic activity. Blockade of dopaminergic receptors by haloperidol or pimozide produced a potentiation of morphine analgesia, while stimulation of dopaminergic activity by L-dopa methyl ester inhibited morphine analgesia. Morphine-induced depression of respiratory rate was potentiated by haloperidol and inhibited by pimozide or L-dopa methyl ester. These results suggest that the dopaminergic system plays a modulating role in morphine-induced analgesia, but not morphine-induced respiratory depression. © 1979.

引用

页码：61 / 68

页数：8

共 35 条

[1] IRRITATING PROPERTIES OF AIRBORNE MATERIALS TO UPPER RESPIRATORY TRACT [J].