EFFECT OF TAURINE ON PASSIVE ION-TRANSPORT IN RAT-BRAIN SYNAPTOSOMES

被引：16

作者：

REMTULLA, MA

KATZ, S

APPLEGARTH, DA

机构：

[1] UNIV BRITISH COLUMBIA,FAC PHARMACEUT SCI,DIV PHARMACOL,VANCOUVER V6T 1W5,BC,CANADA

[2] UNIV BRITISH COLUMBIA,FAC MED,DEPT PAEDIAT,VANCOUVER V6T 1W5,BC,CANADA

[3] UNIV BRITISH COLUMBIA,FAC MED,DEPT PATHOL,VANCOUVER V6T 1W5,BC,CANADA

[4] CHILDRENS HOSP,BIOCHEM DIS LAB,VANCOUVER,BC,CANADA

来源：

LIFE SCIENCES | 1979年 / 24卷 / 20期

关键词：

D O I：

10.1016/0024-3205(79)90240-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Taurine, in concentrations greater than 10 mM, was found to have an inhibitory effect on passive calcium uptake and release in rat brain synaptosomal preparations. Amino acids similar to that of taurine in chemical structure, β-alanine, hypotaurine, homotaurine and γ-amino-butyric acid were also shown to inhibit calcium uptake in this preparation. Taurine, though, did not alter the permeability of these preparations to sodium or potassium. It thus appears that taurine and chemically related amino acids can alter calcium movements in these preparations. It is postulated that this effect is due to binding to specific taurine sites in the synaptosomal membranes. © 1979.

引用

页码：1885 / 1892

页数：8

共 31 条

[1] NEUROPHARMACOLOGY OF TAURINE [J].