MURINE INFANTILE POLYCYSTIC KIDNEY-DISEASE - A ROLE FOR REDUCED RENAL EPIDERMAL GROWTH-FACTOR

被引：23

作者：

GATTONE, VH

CALVET, JP

机构：

[1] UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL,KANSAS CITY,KS 66103

[2] UNIV KANSAS,MED CTR,DEPT BIOCHEM & MOLEC BIOL,KANSAS CITY,KS 66103

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1991年 / 17卷 / 06期

关键词：

POLYCYSTIC KIDNEY DISEASE; EPIDERMAL GROWTH FACTOR; MOUSE;

D O I：

10.1016/S0272-6386(12)80330-1

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Polycystic kidney disease (PKD) represents a form of renal epithelial hyperplasia. The C57BL/6J-cpk mouse, which has an infantile form of PKD, has a dramatically reduced expression of renal prepro-epidermal growth factor (EGF) mRNA and immunoreactive protein. Since EGF promoted maturation of epithelia in the neonate, the relative lack of renal EGF may contribute to the development of the collecting duct cysts by delaying epithelial maturation. © 1991, National Kidney Foundation, Inc.. All rights reserved.

引用

页码：606 / 607

页数：2

共 7 条

[1] ELEVATED C-MYC PROTOONCOGENE EXPRESSION IN AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY-DISEASE [J].