SYNTHESIS OF AN ARTIFICIAL ANTIGEN THAT CORRESPONDS TO A DISACCHARIDE REPEATING UNIT OF THE CAPSULAR POLYSACCHARIDE OF HAEMOPHILUS-INFLUENZAE TYPE-D - A FACILE SYNTHESIS OF METHYL 2-ACETAMIDO-2-DEOXY-BETA-D-MANNOPYRANOSIDE

被引：35

作者：

CLASSON, B ^{[1
]}

GAREGG, PJ ^{[1
]}

OSCARSON, S ^{[1
]}

TIDEN, AK ^{[1
]}

机构：

[1] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN

来源：

CARBOHYDRATE RESEARCH | 1991年 / 216卷

关键词：

D O I：

10.1016/0008-6215(92)84161-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis is described of p-nitrophenyl 2-acetamido-3-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-mannopyranosiduronic acid, corresponding to the disaccharide repeating unit of the capsular polysaccharide of Haemophilus influenzae type d, which, after conversion of the p-nitro- into a p-amino-phenyl residue, may be attached to a protein to make an artificial antigen for immunological studies. The synthesis incorporates a facile route to the 2-acetamido-2-deoxy-beta-D-mannopyranosyl unit.

引用

页码：187 / 196

页数：10

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