EPINEPHRINE ADMINISTRATION STIMULATES GLUT4 TRANSLOCATION BUT REDUCES GLUCOSE-TRANSPORT IN MUSCLE

被引:44
作者
BONEN, A
MEGENEY, LA
MCCARTHY, SC
MCDERMOTT, JC
TAN, MH
机构
[1] DALHOUSIE UNIV, DEPT MED, HALIFAX B3H 3J5, NS, CANADA
[2] DALHOUSIE UNIV, DEPT BIOCHEM, HALIFAX B3H 3J5, NS, CANADA
关键词
D O I
10.1016/0006-291X(92)91249-P
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
Epinephrine opposes glucose transport in muscle. Therefore, we investigated the effects of epinephrine administration (25μg/100g body weight) on glucose transport and glucose transporters in rat muscle. Ninety minutes after epinephrine injection 3-O-methyl glucose transport was reduced (∼47%) in perfused muscles of the rat hindlimb. Translocation of the insulin-regulatable glucose transporter (GLUT4) in the epinephrine-injected animals was confirmed by the marked increments in the GLUT-4 in the plasma membranes and their concomitant reduction in the intracellular membranes. We speculate a) that it is epinephrine which translocated GLUT4 via a cAMP-linked pathway, and b) that the intrinsic activity reductions are caused either by the glycation of the transporter by the persistent hyperglycemia and/or by epinephrine via the phosphorylation of the GLUT4 transporter protein in muscle. © 1992.
引用
收藏
页码:685 / 691
页数:7
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