ELIMINATION OF CAFFEINE INTERFERENCE IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF COTININE IN HUMAN PLASMA

被引：17

作者：

PICHINI, S

ALTIERI, I

PACIFICI, R

ROSA, M

ZUCCARO, P

机构：

[1] Clinical Biochemistry Department, Istituto Superiore di Sanità, 00161 Rome

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 568卷 / 01期

关键词：

D O I：

10.1016/0378-4347(91)80363-H

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic method with ultraviolet photometric detection for the determination of cotinine in human plasma was described. The use of a 30-cm reversed-phase column and of a mobile phase consisting of water-methanol-0.1 M sodium acetate-acetonitrile (72:21:5.6:1.4, v/v), pH 4.1, eliminated caffeine interference. A simplified solid-phase extraction procedure was also performed for plasma samples.

引用

页码：267 / 269

页数：3

共 6 条

[1]

HOLEY NJ, 1983, AM J PUBLIC HEALTH, V73, P1204

[2] IMPROVED GAS-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF NICOTINE AND COTININE IN BIOLOGIC FLUIDS [J].

JACOB, P ;

WILSON, M ;

BENOWITZ, NL .

JOURNAL OF CHROMATOGRAPHY, 1981, 222 (01) :61-70

[3]

LANGONE JJ, 1982, METHOD ENZYMOL, V84, P628

[4] NICOTINE METABOLITES IN THE URINE OF SMOKERS [J].

PARVIAINEN, MT ;

PUHAKAINEN, EVJ ;

LAATIKAINEN, R ;

SAVOLAINEN, K ;

HERRANEN, J ;

BARLOW, RD .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 525 (01) :193-202

[5]

SIOUFI A, 1989, METHOD FIND EXP CLIN, V11, P179

[6]

THUAN NTL, 1989, CLIN CHEM, V35, P1456

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