CYTOCHROME-P450 AND THE ARACHIDONATE CASCADE

被引：286

作者：

CAPDEVILA, JH

FALCK, JR

ESTABROOK, RW

机构：

[1] VANDERBILT UNIV, DEPT BIOCHEM, NASHVILLE, TN 37232 USA

[2] UNIV TEXAS, SW MED CTR, DEPT MOLEC GENET, DALLAS, TX 75235 USA

[3] UNIV TEXAS, SW MED CTR, DEPT BIOCHEM, DALLAS, TX 75235 USA

[4] UNIV TEXAS, SW MED CTR, CECIL H & IDA GREEN CTR REPROD BIOL SCI, DALLAS, TX 75235 USA

来源：

FASEB JOURNAL | 1992年 / 6卷 / 02期

关键词：

P450; ARACHIDONATE; EICOSANOIDS; EPOXYGENASE; PROSTANOIDS; HYDROXYEICOSATETRAENOIC ACIDS; OMEGA OXIDATION;

D O I：

10.1096/fasebj.6.2.1537463

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.

引用

收藏

页码：731 / 736

页数：6

相关论文

共 40 条

[1]

SELECTIVE INCORPORATION OF (15S)-HYDROXYEICOSATETRAENOIC ACID IN PHOSPHATIDYLINOSITOL OF HUMAN NEUTROPHILS - AGONIST-INDUCED DEACYLATION AND TRANSFORMATION OF STORED HYDROXYEICOSANOIDS [J].

BREZINSKI, ME ;

SERHAN, CN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) :6248-6252

[2]

ABSOLUTE-CONFIGURATION OF THE HYDROXYEICOSATETRAENOIC ACIDS (HETES) FORMED DURING CATALYTIC OXYGENATION OF ARACHIDONIC-ACID BY MICROSOMAL CYTOCHROME-P-450 [J].

CAPDEVILA, J ;

YADAGIRI, P ;

MANNA, S ;

FALCK, JR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 141 (03) :1007-1011

[3]

INFLUENCE OF A FIBRIC ACID TYPE OF HYPOLIPIDEMIC AGENT ON THE OXIDATIVE-METABOLISM OF ARACHIDONIC-ACID BY LIVER MICROSOMAL CYTOCHROME-P-450 [J].

CAPDEVILA, J ;

KIM, YR ;

WIXTROM, CM ;

FALCK, JR ;

MANNA, S ;

ESTABROOK, RW .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 243 (01) :8-19

[4]

CAPDEVILA J, 1983, ENDOCRINOLOGY, V113, P421

[5]

LIVER MICROSOMAL CYTOCHROME-P-450 AND THE OXIDATIVE-METABOLISM OF ARACHIDONIC-ACID [J].

CAPDEVILA, J ;

CHACOS, N ;

WERRINGLOER, J ;

PROUGH, RA ;

ESTABROOK, RW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (09) :5362-5366

[6]

THE MECHANISTIC PLURALITY OF CYTOCHROME-P-450 AND ITS BIOLOGICAL RAMIFICATIONS [J].

CAPDEVILA, J ;

SAEKI, Y ;

FALCK, JR .

XENOBIOTICA, 1984, 14 (1-2) :105-118

[7]

THE OXIDATIVE-METABOLISM OF ARACHIDONIC-ACID BY PURIFIED CYTOCHROMES P-450 [J].

CAPDEVILA, J ;

PARKHILL, L ;

CHACOS, N ;

OKITA, R ;

MASTERS, BSS ;

ESTABROOK, RW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 101 (04) :1357-1363

[8]

CAPDEVILA JH, 1990, J BIOL CHEM, V265, P10865

[9]

ENDOGENOUS BIOSYNTHESIS OF ARACHIDONIC-ACID EPOXIDES IN HUMANS - INCREASED FORMATION IN PREGNANCY-INDUCED HYPERTENSION [J].

CATELLA, F ;

LAWSON, JA ;

FITZGERALD, DJ ;

FITZGERALD, GA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) :5893-5897

[10]

PLATELET CYTOCHROME-P-450 - POSSIBLE ROLE IN ARACHIDONATE-INDUCED AGGREGATION [J].

CINTI, DL ;

FEINSTEIN, MB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 73 (01) :171-179

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