ASYMMETRIC-SYNTHESIS OF (2S,3R) BETA-(4-F-3-NO2) PHENYL SERINE, D-(R)-4-METHOXY-3,5-BIS(T)BUTYLDIMETHYLSILOXY PHENYLGLYCINE AND THEIR ASSEMBLAGE TO C-O-D RING OF VANCOMYCIN

被引：46

作者：

ZHU, JP

BOUILLON, JP

SINGH, GP

CHASTANET, J

BEUGELMANS, R

机构：

[1] Institut de Chimie des Substances Naturelles, CNRS

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 39期

关键词：

D O I：

10.1016/0040-4039(95)01409-B

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric synthesis of two appropriately functionalized non-proteinogenic amino acids 2 and 3 needed for the total synthesis of vancomycin was described. The assemblage of these amino acids into linear tripeptide followed by biaryl ether formation via intramolecular SNAr reaction led to the fully functionalized C-O-D ring of vancomycin.

引用

页码：7081 / 7084

页数：4

共 30 条

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