A HIGH-RESOLUTION DELETION MAP OF HUMAN CHROMOSOME-XP22

被引：100

作者：

SCHAEFER, L

FERRERO, GB

GRILLO, A

BASSI, MT

ROTH, EJ

WAPENAAR, MC

VANOMMEN, GJB

MOHANDAS, TK

ROCCHI, M

ZOGHBI, HY

BALLABIO, A

机构：

[1] BAYLOR COLL MED,INST MOLEC GENET,HOUSTON,TX 77030

[2] BAYLOR COLL MED,DEPT PEDIAT,HOUSTON,TX 77030

[3] BAYLOR COLL MED,CTR HUMAN GENOME,HOUSTON,TX 77030

[4] LEIDEN UNIV,DEPT HUMAN GENET,2333 AL LEIDEN,NETHERLANDS

[5] UCLA,HARBOR MED CTR,DIV MED GENET,TORRANCE,CA 90509

[6] UNIV BARI,IST GENET,I-70126 BARI,ITALY

来源：

NATURE GENETICS | 1993年 / 4卷 / 03期

关键词：

D O I：

10.1038/ng0793-272

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have developed a 32-interval deletion panel for human chromosome Xp22 spanning about 30 megabases of genomic DNA. DNA samples from 50 patients with chromosomal rearrangements involving Xp22 were tested with 60 markers using a polymerase chain reaction strategy. The ensuing deletion map allowed us to confirm and refine the order of previously isolated and newly developed markers. Our mapping panel will provide the framework for mapping new sequences, for orienting chromosome walks in the region and for projects aimed at isolating genes responsible for diseases mapping to Xp22.

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页码：272 / 279

页数：8

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