PRIMIDONE METABOLISM IN RENAL-INSUFFICIENCY AND ACUTE INTOXICATION

被引:14
作者
HEIPERTZ, R [1 ]
GUTHOFF, A [1 ]
BERNHARDT, W [1 ]
机构
[1] UNIV HAMBURG,KRANKENHAUS EPPENDORF,MED KLIN 1,D-2000 HAMBURG 20,FED REP GER
关键词
Intoxication acute renal insufficiency; Overdosage chronic; Patient compliance; Phenobarbital concentration relative; Primidone metabolism;
D O I
10.1007/BF00313107
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Primidone (PRIM) is metabolized into phenobarbital (PB) and phenylethylmalonamide (PEMA). During anticonvulsant therapy with PRIM under normal conditions PB represents by far the largest portion of the total concentration of all three components (PRIM + PB + PEMA). In combined therapy with diphenylhydantoin (DPH), and during chronic PRIM overdosage, the relative concentration of PB is even higher. A case of renal insufficiency while on PRIM therapy and a case of acute PRIM intoxication are presented. In both cases PRIM and PEMA are elevated while PB is relatively low. The mechanisms involved in this phenomenon are discussed. Excluding young children with chronic PRIM overdosage, and the endogenous and exogenous intoxication described here, a relative PB concentration below 40% indicates a lack of patient compliance if a steady treatment schedule has been maintained for at least 3 weeks. © 1979 Springer-Verlag.
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收藏
页码:101 / 104
页数:4
相关论文
共 7 条
[1]  
[Anonymous], [No title captured]
[2]   METABOLIC DISPOSITION OF PRIMIDONE AND ITS METABOLITES IN EPILEPTIC SUBJECTS AFTER SINGLE AND REPEATED ADMINISTRATION [J].
GALLAGHER, BB ;
BAUMEL, IP ;
MATTSON, RH .
NEUROLOGY, 1972, 22 (11) :1186-+
[3]  
GALLAGHER BB, 1972, ANTIEPILEPTIC DRUGS, P361
[4]   EVALUATION OF A RAPID GAS-CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS QUANTITATIVE-DETERMINATION OF ETHOSUXIMIDE, PHENYLETHEYLMALONEDIAMIDE, CARBAMAZEPINE, PHENOBARBITAL, PRIMIDONE AND DIPHENYLHYDANTOIN IN HUMAN-SERUM [J].
HEIPERTZ, R ;
PILZ, H ;
EICKHOFF, K .
CLINICA CHIMICA ACTA, 1977, 77 (03) :307-316
[5]   SELECTED CLINICAL ASPECTS OF ROUTINE MONITORING OF ANTICONVULSANT CONCENTRATIONS IN SERUM [J].
HEIPERTZ, R ;
PILZ, H ;
EICKHOFF, K ;
SEIDEL, D .
ARCHIV FUR PSYCHIATRIE UND NERVENKRANKHEITEN, 1977, 224 (04) :361-378
[6]  
SCHAFER H, 1976, EPILEPTOLOGY, P139
[7]   POSSIBLE PHENYLETHYLMALONDIAMIDE (PEMA) INTOXICATION [J].
STERN, EL .
ANNALS OF NEUROLOGY, 1977, 2 (04) :356-357