ANTIGENIC VARIATION OF HUMAN AND BOVINE PARAINFLUENZA VIRUS TYPE-3 STRAINS

被引:15
作者
KLIPPMARK, E [1 ]
RYDBECK, R [1 ]
SHIBUTA, H [1 ]
NORRBY, E [1 ]
机构
[1] UNIV TOKYO,INST MED SCI,DEPT VIRAL INFECT,MINATO KU,TOKYO 108,JAPAN
关键词
D O I
10.1099/0022-1317-71-7-1577
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Three human and six bovine parainfluenza virus type 3 (PIV3) strains were examined by the use of 60 monoclonal antibodies (MAbs). Fifty-three MAbs to the human C243 strain were directed against six, four, nine and seven epitopes of the haemagglutinin-neuraminidase (HN), fusion (F), nucleocapsid (N) and matrix proteins, respectively. Seven MAbs to the bovine strain were directed against three epitopes of the HN protein and three epitopes of the F protein. Each strain was characterized in ELISA and immunofluorescence tests with all MAbs and in a haemagglutination inhibition assay with the anti-HN MAbs. There were marked differences between human and bovine viruses, primarily in the HN protein where five epitopes differed. One epitope of the F and one of the N protein also differed. Bovine PIV3 was found to be a homogeneous subtype and distinct from human PIV3.
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页码:1577 / 1580
页数:4
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