THE DISCRIMINATIVE STIMULUS EFFECT OF MK-801 IN KETAMINE-TRAINED RATS

被引：8

作者：

BENVENGA, MJ

WING, AV

DELVECCHIO, RA

机构：

[1] Department of Pharmacology, Murray Hill, NJ 07974

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 38卷 / 01期

关键词：

KETAMINE; PHENCYCLIDINE; MK-801; DRUG DISCRIMINATION;

D O I：

10.1016/0091-3057(91)90613-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate] was assessed for its discriminative stimulus properties in rats trained to discriminate ketamine (7 mg/kg) from vehicle. MK-801 generalized to ketamine in a dose dependent manner with a maximum effect at 0.2 mg/kg, while ketamine generalized fully at 10 mg/kg. These results indicate that ketamine and MK-801 may share a common mechanism of action, which is related to the phencyclidine recognition site in the brain.

引用

页码：211 / 213

页数：3

共 10 条

[1] THE DISSOCIATIVE ANESTHETICS, KETAMINE AND PHENCYCLIDINE, SELECTIVELY REDUCE EXCITATION OF CENTRAL MAMMALIAN NEURONS BY N-METHYL-ASPARTATE
ANIS, NA
BERRY, SC
BURTON, NR
LODGE, D
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1983, 79 (02) : 565 - 575
[2] THE COMPETITIVE N-METHYL-D-ASPARTATE (NMDA) ANTAGONIST CGS-19755 ATTENUATES THE RATE-DECREASING EFFECTS OF NMDA IN RHESUS-MONKEYS WITHOUT PRODUCING KETAMINE-LIKE DISCRIMINATIVE STIMULUS EFFECTS
FRANCE, CP
WOODS, JH
ORNSTEIN, P
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 159 (02) : 133 - 139
[3] KOEK W, 1988, J PHARMACOL EXP THER, V245, P969
[4] DISCRIMINATIVE STIMULUS PROPERTIES OF PHENCYCLIDINE (PCP)-RELATED COMPOUNDS - CORRELATIONS WITH H-3 PCP BINDING POTENCY MEASURED AUTORADIOGRAPHICALLY
KOZLOWSKI, MR
BROWNE, RG
VINICK, FJ
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 25 (05) : 1051 - 1058
[5] THE NOVEL ANTICONVULSANT MK-801 INTERACTS WITH CENTRAL PHENCYCLIDINE RECOGNITION SITES IN RAT-BRAIN
LOO, PA
BRAUNWALDER, AF
WILLIAMS, M
SILLS, MA
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 135 (02) : 261 - 263
[6] THE NOVEL ANTICONVULSANT MK-801 - A POTENT AND SPECIFIC LIGAND OF THE BRAIN PHENCYCLIDINE SIGMA-RECEPTOR
SIRCAR, R
RAPPAPORT, M
NICHTENHAUSER, R
ZUKIN, SR
[J]. BRAIN RESEARCH, 1987, 435 (1-2) : 235 - 240
[7] THE BEHAVIORAL-EFFECTS OF MK-801 - A COMPARISON WITH ANTAGONISTS ACTING NON-COMPETITIVELY AND COMPETITIVELY AT THE NMDA RECEPTOR
TRICKLEBANK, MD
SINGH, L
OLES, RJ
PRESTON, C
IVERSEN, SD
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 167 (01) : 127 - 135
[8] PHENCYCLIDINE-LIKE DISCRIMINATIVE STIMULUS PROPERTIES OF MK-801 IN RATS
WILLETTS, J
BALSTER, RL
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 146 (01) : 167 - 169
[9] THE ANTICONVULSANT MK-801 IS A POTENT N-METHYL-D-ASPARTATE ANTAGONIST
WONG, EHF
KEMP, JA
PRIESTLEY, T
KNIGHT, AR
WOODRUFF, GN
IVERSEN, LL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (18) : 7104 - 7108
[10] BEHAVIORAL AND BIOCHEMICAL STEREOSELECTIVITY OF SIGMA OPIATE PCP RECEPTORS
ZUKIN, SR
BRADY, KT
SLIFER, BL
BALSTER, RL
[J]. BRAIN RESEARCH, 1984, 294 (01) : 174 - 177

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