CYTOTOXIC EFFECTS OF FOOD-ADDITIVES AND PHARMACEUTICALS ON CELLS IN CULTURE AS DETERMINED WITH THE NEUTRAL RED ASSAY

被引：39

作者：

BABICH, H ^{[1
]}

BORENFREUND, E ^{[1
]}

机构：

[1] ROCKEFELLER UNIV, LAB ANIM RES CTR, NEW YORK, NY 10021 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1990年 / 79卷 / 07期

关键词：

D O I：

10.1002/jps.2600790709

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The acute cytotoxicity of butylated hydroxytoluene and butylated hydroxyanisole to cultured human dermal fibroblasts, keratinocytes, melanocytes, and melanoma tumor cells was determined with the neutral red assay. For all cell types, butylated hydroxytoluene proved to be more cytotoxic than butylated hydroxyanisole. The neutral red assay is a rapid, economical, semiautomated assay that can be used with a variety of cell types in culture to provide quantitated data that can be used to rank test agents according to their potencies. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：592 / 594

页数：3

共 23 条

[1] ARSENIC-SELENIUM INTERACTIONS DETERMINED WITH CULTURED FISH CELLS
BABICH, H
MARTINALGUACIL, N
BORENFREUND, E
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[2] STRUCTURE ACTIVITY RELATIONSHIP (SAR) MODELS ESTABLISHED INVITRO WITH THE NEUTRAL RED CYTOTOXICITY ASSAY
BABICH, H
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[3] ACUTE CYTOTOXICITIES OF POLYNUCLEAR AROMATIC-HYDROCARBONS DETERMINED INVITRO WITH THE HUMAN-LIVER TUMOR-CELL LINE, HEPG2
BABICH, H
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BORENFREUND, E
[J]. CELL BIOLOGY AND TOXICOLOGY, 1988, 4 (03) : 295 - 309
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BABICH, H
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[5] Babich H, 1987, Mol Toxicol, V1, P363
[6] STRUCTURE ACTIVITY RELATIONSHIPS FOR DIORGANOTINS, CHLORINATED BENZENES AND CHLORINATED ANILINES ESTABLISHED WITH BLUEGILL SUNFISH BF-2 CELLS
BABICH, H
BORENFREUND, E
[J]. FUNDAMENTAL AND APPLIED TOXICOLOGY, 1988, 10 (02): : 295 - 301
[7] Borenfreud E, 1984, METHODS CELL SCI, V9, P7, DOI DOI 10.1007/BF01666038
[8] CYTOTOXICITY OF METALS, METAL-METAL AND METAL-CHELATOR COMBINATIONS ASSAYED INVITRO
BORENFREUND, E
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[J]. TOXICOLOGY, 1986, 39 (02) : 121 - 134
[9] SHORT-TERM QUANTITATIVE INVITRO CYTOTOXICITY ASSAY INVOLVING AN S-9 ACTIVATING SYSTEM
BORENFREUND, E
PUERNER, JA
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[10] COMPARISONS OF 2-INVITRO CYTO-TOXICITY ASSAYS - THE NEUTRAL RED (NR) AND TETRAZOLIUM MTT TESTS
BORENFREUND, E
BABICH, H
MARTINALGUACIL, N
[J]. TOXICOLOGY IN VITRO, 1988, 2 (01) : 1 - 6

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