INDUCTION OF AUTOLYSIS IN ENTEROCOCCUS-FAECALIS S-47 BY PEPTIDE AS-48

被引：22

作者：

GALVEZ, A

VALDIVIA, E

MARTINEZBUENO, M

MAQUEDA, M

机构：

[1] Facultad de Ciencias, Universidad de Granada, Maqueda Departamenta de Microbiologia, Granada

来源：

JOURNAL OF APPLIED BACTERIOLOGY | 1990年 / 69卷 / 03期

关键词：

D O I：

10.1111/j.1365-2672.1990.tb01531.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In addition to its bactericidal mode of action, the peptide antibiotic AS‐48 exhibits a bacteriolytic effect on Enterococcus faecalis S‐47 that is associated with autolysin activation. Bacteriolysis induced by the antibiotic can be modulated by addition of EDTA, divalent cations and autolysin activators (trypsin) or inhibitors (cardiolipin), suggesting that topologic regulation of the autolysins is involved in the process. In addition, inhibitors of protein and RNA synthesis interfere markedly with bacteriolysis, as do ionophores and the ATPase inhibitor DCCD, suggesting the participation of an internal messenger in autolysin activation in the presence of AS‐48. Copyright © 1990, Wiley Blackwell. All rights reserved

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页码：406 / 413

页数：8

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