SURVIVAL OF APURINIC SV40-DNA IN THE D-COMPLEMENTATION GROUP OF XERODERMA PIGMENTOSUM

被引：12

作者：

KUDRNA, RD ^{[1
]}

SMITH, J ^{[1
]}

LINN, S ^{[1
]}

PENHOET, EE ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT BIOCHEM,BERKELEY,CA 94720

来源：

MUTATION RESEARCH | 1979年 / 62卷 / 01期

关键词：

D O I：

10.1016/0027-5107(79)90230-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The survival of depurinated Form I SV40 DNA was studied in normal human fibroblasts and in D-complementation Xeroderma pigmentosum (XP) fibroblasts. Survival was measured with an infective center assay. Heat-acid and methyl methanesulfonate (MMS) were used as depurinating agents. After 3 hrs of depurination by heat-acid treatment, infectivity in normal cells was less than 15% of the controls compared to more than 50% for the XP D cell strains. Similar results were obtained with MMS-treated DNA. These results are contrary to expectation since apurinic endonuclease activity, which is presumed to be involved in the repair of apurinic sites, is much lower in XP D cell strains than in normal cell strains. Our results indicate that another mechanism for the repair of apurinic sites could exist. © 1979.

引用

页码：173 / 181

页数：9

共 33 条

[1] HOST-CELL REACTIVATION OF ULTRAVIOLET-IRRADIATED SV40-DNA IN 5 COMPLEMENTATION GROUPS OF XERODERMA PIGMENTOSUM [J].

ABRAHAMS, PJ ;

VANDEREB, AJ .

MUTATION RESEARCH, 1976, 35 (01) :13-22

[2] DIFFERENT INHERITED LEVELS OF DNA REPAIR REPLICATION IN XERODERMA PIGMENTOSUM CELL STRAINS AFTER EXPOSURE TO ULTRAVIOLET IRRADIATION [J].

BOOTSMA, D ;

MULDER, MP ;

POT, F ;

COHEN, JA .

MUTATION RESEARCH, 1970, 9 (05) :507-&

[3]

BOOTSMA D, 1978, DNA REPAIR MECHANISM, P589

[4] REPAIR OF DEPURINATED DNA INVITRO BY ENZYMES PURIFIED FROM HUMAN LYMPHOBLASTS [J].

BOSE, K ;

KARRAN, P ;

STRAUSS, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (02) :794-798

[5] DNA REPAIR AND RADIATION SENSITIVITY IN HUMAN (XERODERMA PIGMENTOSUM) CELLS [J].

CLEAVER, JE .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE, 1970, 18 (06) :557-&

[6] DEFECTIVE REPAIR REPLICATION OF DNA IN XERODERMA PIGMENTOSUM [J].

CLEAVER, JE .

NATURE, 1968, 218 (5142) :652-&

[7] ABSENCE OF EXCISION OF ULTRAVIOLET-INDUCED CYCLOBUTANE DIMERS IN XERODERMA PIGMENTOSUM [J].

CLEAVER, JE ;

TROSKO, JE .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1970, 11 (06) :547-&

[8] XERODERMA PIGMENTOSUM - A HUMAN DISEASE IN WHICH AN INITIAL STAGE OF DNA REPAIR IS DEFECTIVE [J].

CLEAVER, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1969, 63 (02) :428-&

[9] XERODERMA PIGMENTOSUM - BIOCHEMICAL AND GENETIC CHARACTERISTICS [J].

CLEAVER, JE ;

BOOTSMA, D .

ANNUAL REVIEW OF GENETICS, 1975, 9 :19-38

[10]

FARKAS WR, 1973, J BIOL CHEM, V248, P7780

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