THE EFFECT OF MALARIA INFECTION ON 3'-AZIDO-3'-DEOXYTHYMIDINE AND PARACETAMOL GLUCURONIDATION IN RAT-LIVER MICROSOMES

被引：7

作者：

ISMAIL, S

BACK, DJ

EDWARDS, G

机构：

[1] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,POB 147,LIVERPOOL L69 3BS,ENGLAND

[2] UNIV LIVERPOOL,LIVERPOOL SCH TROP MED,DIV BIOMED SCI,LIVERPOOL L3 5QA,ENGLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 09期

关键词：

D O I：

10.1016/0006-2952(92)90084-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of malaria infection on UDP-glucuronosyltransferase (UDPGT) activity was investigated in rat liver microsomes using 3'-azido-3'-deoxythymidine and paracetamol. The Michaelis-Menten parameters, K(m) and V(max) were calculated and intrinsic clearance values were estimated for normal and infected livers. The results show that malaria infection alters the activity of UDPGT.

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页码：1879 / 1882

页数：4

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