NEURAL CELL-ADHESION MOLECULE (NCAM) AND PERINEURAL INVASION IN BILE-DUCT CANCER

被引：59

作者：

SEKI, H ^{[1
]}

TANAKA, J ^{[1
]}

SATO, Y ^{[1
]}

KATO, Y ^{[1
]}

UMEZAWA, A ^{[1
]}

KOYAMA, K ^{[1
]}

机构：

[1] AKITA UNIV,SCH MED,DEPT SURG,1-1-1 HONDO,AKITA 010,JAPAN

来源：

JOURNAL OF SURGICAL ONCOLOGY | 1993年 / 53卷 / 02期

关键词：

NEURAL CELL ADHESION MOLECULE (NCAM); PERINEURAL INVASION; BILE DUCT CANCER; IMMUNOHISTOCHEMICAL STAINING;

D O I：

10.1002/jso.2930530205

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Perineural invasion is associated with tumor spreading and an unfavorable prognosis in a variety of cancers. Recently, neural cell adhesion molecule (NCAM) has been reported to be affinitive to neural tissues, which suggests some relationship between NCAM and perineural invasion. This study was designed to elucidate the role of the expression of NCAM on the development of perineural invasion in bile duct cancer. A histopathologic study was performed on 24 patients with bile duct carcinoma who underwent resections. The overall incidence of NCAM expression in the resected specimen was 66.7% and that of perineural invasion was 87.5%. Furthermore, NCAM expression was shown to be positive in 16 (76%) out of 21 cases in whom perineural invasion was observed. A significant positive correlation was found between the expression of NCAM and perineural invasion in bile duct cancer. These results highlight an important role of NCAM in the development of perineural invasion in bile duct cancer.

引用

页码：78 / 83

页数：6

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