THERAPEUTIC POTENTIAL OF INSULIN-LIKE GROWTH FACTOR-I

被引：49

作者：

FROESCH, ER ^{[1
]}

GULER, HP ^{[1
]}

SCHMID, C ^{[1
]}

BINZ, K ^{[1
]}

ZAPF, J ^{[1
]}

机构：

[1] CIBA GEIGY CORP,DIV PHARMACEUT,SUMMIT,NJ 07901

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1990年 / 1卷 / 05期

关键词：

D O I：

10.1016/1043-2760(90)90006-O

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human recombinant insulinlike growth factor I is a promising therapeutic agent for diseases characterized by relative insulin resistance, e.g., diabetes mellitus, obesity, and hypertriglyceridemia, since it suppresses growth hormone, insulin, C-peptide, and triglyceride levels and lowers the total cholesterol to high-density lipoprotein-cholesterol ratio. Moreover, insulinlike growth factor administration increases kidney function in healthy subjects (glomerular filtration rate, renal plasma flow) and may prove useful in the treatment of degenerative disorders of cartilage and bone (arthrosis, osteoporosis) as well as in catabolic states. © 1990.

引用

页码：254 / 260

页数：7

共 41 条

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