RESOLUTION OF THE ENANTIOMERS OF OMEPRAZOLE AND SOME OF ITS ANALOGS BY LIQUID-CHROMATOGRAPHY ON A TRISPHENYLCARBAMOYLCELLULOSE-BASED STATIONARY PHASE - THE EFFECT OF THE ENANTIOMERS OF OMEPRAZOLE ON GASTRIC GLANDS

被引：65

作者：

ERLANDSSON, P

ISAKSSON, R

LORENTZON, P

LINDBERG, P

机构：

[1] UNIV LUND,CTR CHEM,DIV ORGAN CHEM 3,S-22100 LUND,SWEDEN

[2] HASSLE GASTROINTESTINAL RES LABS,DEPT BIOL & ORGAN CHEM,S-43183 MOLNDAL,SWEDEN

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 532卷 / 02期

关键词：

D O I：

10.1016/S0378-4347(00)83781-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The enantiomers of omeprazole and some of its analogues have been separated on a chiral stationary phase comprising trisphenylcarbamoylcellulose coated on 3-aminopropyl silica. The nature of the supporting silica has a crucial effect on the separations obtained. The racemisation half-life of omeprazole was estimated to be 1.3 · 102 h at 37°C. In vitro tests on isolated gastric glands from rabbits showed that both enantiomers of omeprazole had an inhibitory effect on acid formation. © 1990.

引用

页码：305 / 319

页数：15

共 25 条

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