LAMOTRIGINE IN RETT-SYNDROME

被引:55
作者
ULDALL, P
HANSEN, FJ
TONNBY, B
机构
[1] RIGSHOSP,DEPT PEDIAT,DK-2100 COPENHAGEN,DENMARK
[2] HABILITAT UNIT,HALMSTAD,SWEDEN
关键词
RETT SYNDROME; SEIZURES; LAMOTRIGINE;
D O I
10.1055/s-2008-1071568
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
An elevated CSF glutamate level has recently been reported in Rett syndrome. Because the anticonvulsant effect of Lamotrigine is probably due to inhibition of glutamate release, this drug was given as an add-on drug to 4 girls with Rett syndrome. All patients responded with a seizure reduction of 50% or more and an improved well-being. A controlled study at the early stages of the syndrome could be interesting.
引用
收藏
页码:339 / 340
页数:2
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