THE HIV PROTEIN, GP120, ACTIVATES NUCLEAR-PROTEIN KINASE-C IN NUCLEI FROM LYMPHOCYTES AND BRAIN

被引：25

作者：

ZORN, NE

WEILL, CL

RUSSELL, DH

机构：

[1] LOUISIANA STATE UNIV,MED CTR,DEPT NEUROL,NEW ORLEANS,LA 70112

[2] LOUISIANA STATE UNIV,MED CTR,DEPT ANAT,NEW ORLEANS,LA 70112

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)90984-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear pool(s) of protein kinase C (PKC) may be a common target for hormones and growth factors which affect the trophic state of cells. The data presented demonstrate a time and dose-dependent activation of nuclear PKC by the HIV coat protein, gp120, in isolated nuclei from rat spleen and hippocampus. This gp120-stimulated PKC response was blocked by specific PKC inhibitors, a monoclonal antibody to PKC, and a monoclonal antibody directed against the murine T4 analog, L3T4. It is suggested that the gp120 interaction with the nuclear trophic factor-PKC system may impair normal gene expression, and thus result in the clinical symptoms associated in AIDS infection. © 1990.

引用

收藏

页码：1133 / 1139

页数：7

相关论文

共 25 条

[1] NEURONAL CELL KILLING BY THE ENVELOPE PROTEIN OF HIV AND ITS PREVENTION BY VASOACTIVE INTESTINAL PEPTIDE [J].

BRENNEMAN, DE ;

WESTBROOK, GL ;

FITZGERALD, SP ;

ENNIST, DL ;

ELKINS, KL ;

RUFF, MR ;

PERT, CB .

NATURE, 1988, 335 (6191) :639-642

[2] NONNEURONAL CELLS MEDIATE NEUROTROPHIC ACTION OF VASOACTIVE-INTESTINAL-PEPTIDE [J].

BRENNEMAN, DE ;

NEALE, EA ;

FOSTER, GA ;

DAUTREMONT, SW ;

WESTBROOK, GL .

JOURNAL OF CELL BIOLOGY, 1987, 104 (06) :1603-1610

[3] PEPTIDE-T SEQUENCES PREVENT NEURONAL CELL-DEATH PRODUCED BY THE ENVELOPE PROTEIN (GP120) OF THE HUMAN IMMUNODEFICIENCY VIRUS [J].

BRENNEMAN, DE ;

BUZY, JM ;

RUFF, MR ;

PERT, CB .

DRUG DEVELOPMENT RESEARCH, 1988, 15 (04) :361-369

[4] RAPID ACTIVATION OF PROTEIN KINASE-C IN ISOLATED RAT-LIVER NUCLEI BY PROLACTIN, A KNOWN HEPATIC MITOGEN [J].

BUCKLEY, AR ;

CROWE, PD ;

RUSSELL, DH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (22) :8649-8653

[5] THE ASSOCIATION OF POLYPEPTIDE HORMONES AND GROWTH-FACTORS WITH THE NUCLEI OF TARGET-CELLS [J].

BURWEN, SJ ;

JONES, AL .

TRENDS IN BIOCHEMICAL SCIENCES, 1987, 12 (04) :159-162

[6] IA BINDING LIGANDS AND CAMP STIMULATE NUCLEAR TRANSLOCATION OF PKC IN LYMPHOCYTES-B [J].

CAMBIER, JC ;

NEWELL, MK ;

JUSTEMENT, LB ;

MCGUIRE, JC ;

LEACH, KL ;

CHEN, ZZ .

NATURE, 1987, 327 (6123) :629-632

[7] IMMUNOCHEMICAL CHARACTERIZATION OF PROTEIN-KINASE-C IN RAT-LIVER NUCLEI AND SUBNUCLEAR FRACTIONS [J].

CAPITANI, S ;

GIRARD, PR ;

MAZZEI, GJ ;

KUO, JF ;

BEREZNEY, R ;

MANZOLI, FA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (02) :367-375

[8] LYSOSPHINGOLIPIDS INHIBIT PROTEIN-KINASE-C - IMPLICATIONS FOR THE SPHINGOLIPIDOSES [J].

HANNUN, YA ;

BELL, RM .

SCIENCE, 1987, 235 (4789) :670-674

[9] SPECIFIC BINDING OF PHORBOL ESTERS TO NUCLEI OF HUMAN PROMYELOCYTIC LEUKEMIA-CELLS [J].

KRAFT, AS ;

APPLING, C ;

BERKOW, RL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 144 (01) :393-401

[10] DELINEATION OF A REGION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP120 GLYCOPROTEIN CRITICAL FOR INTERACTION WITH THE CD4 RECEPTOR [J].

LASKY, LA ;

NAKAMURA, G ;

SMITH, DH ;

FENNIE, C ;

SHIMASAKI, C ;

PATZER, E ;

BERMAN, P ;

GREGORY, T ;

CAPON, DJ .

CELL, 1987, 50 (06) :975-985