PROMOTION OF EPITHELIAL KERATINIZATION BY N-METHYL-N'-NITRO-N-NITROSOGUANIDINE IN RAT FORESTOMACH IN ORGAN-CULTURE

被引：5

作者：

FUKAMACHI, H

TAKAYAMA, S

机构：

[1] Zoological Institute, Faculty of Science, University of Tokyo, Tokyo

[2] Department of Experimental Pathology, Cancer Institute, Tokyo, 170, I-37-1. Kami-Ikebukuro, Toshima-ku

来源：

EXPERIENTIA | 1979年 / 35卷 / 05期

关键词：

D O I：

10.1007/BF01960387

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) on epithelial differentiation of fetal rat forestomach was investigated in organ culture. When forestomach tissues removed from 16.5-day fetuses were treated with 5 μg and 3 μg of MNNG per ml for 1 h, epithelial keratinization was observed after 4 and 5 days, respectively, whereas it occurred after 6 days in control cultures. A clear dose-response relationship was found in the promotion of epithelial keratinization by MNNG. © 1979 Birkhäuser Verlag.

引用

页码：666 / 668

页数：3

共 5 条

[1] ALPHA-RETINYL BETA-RETINYL ACETATE REVERSE METAPLASIAS OF VITAMIN-A-DEFICIENCY IN HAMSTER TRACHEA IN ORGAN-CULTURE [J].