DETECTION OF THE PHILADELPHIA-CHROMOSOME IN INTERPHASE NUCLEI

被引：180

作者：

ARNOLDUS, EPJ

WIEGANT, J

NOORDERMEER, IA

WESSELS, JW

BEVERSTOCK, GC

GROSVELD, GC

VANDERPLOEG, M

RAAP, AK

机构：

[1] ACAD HOSP LEIDEN,DEPT NEUROL,LEIDEN,NETHERLANDS

[2] LEIDEN STATE UNIV,DEPT HUMAN GENET,2333 AL LEIDEN,NETHERLANDS

[3] ERASMUS UNIV,DEPT CELL BIOL & GENET,3000 DR ROTTERDAM,NETHERLANDS

来源：

CYTOGENETICS AND CELL GENETICS | 1990年 / 54卷 / 3-4期

关键词：

D O I：

10.1159/000132972

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Double fluorescence in situ hybridization was used to detect Philadelphia (Ph) chromosomes in interphase nuclei and metaphases of patients with chronic myeloid leukemia. Application of cosmid probes for 3' ABL and 5' BCR sequences gave better results than libraries for chromosomes 9 and 22. The present approach may provide an alternative method for monitoring minimal residual disease in Ph+ CML patients.

引用

页码：108 / &

共 18 条

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