TETRAMETHYLTHIURAM DISULFIDE OR DIMETHYLDITHIOCARBAMATE INDUCES THE SYNTHESIS OF CADYSTINS, HEAVY-METAL CHELATING PEPTIDES, IN SCHIZOSACCHAROMYCES-POMBE

被引：8

作者：

MUTOH, N

KAWABATA, M

HAYASHI, Y

机构：

[1] Department of Genetics, Institute for Developmental Research, Kasugai, Aichi, 480-03, Aichi Prefectural Colony

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)90392-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tetramethylthiuram disulfide (TMTD) or dimethyldithiocarbamate (DMDTC) induces the synthesis of cadystins, a family of heavy metal chelating isopeptides with the formula (γ-Glu-Cys)n-Gly (n=2,3,4,...), in the fission yeast Schizosaccharomyces pombe. Amount of cadystins synthesized in TMTD or DMDTC treated cells is less than that synthesized in CdCl2 treated cells but much more than that synthesized in ZnCl2 or CuSO4 treated cells. © 1991.

引用

页码：1068 / 1073

页数：6

共 19 条

[1] POLY(GAMMA-GLUTAMYLCYSTEINYL)GLYCINE SYNTHESIS IN DATURA-INNOXIA AND BINDING WITH CADMIUM [J].

DELHAIZE, E ;

JACKSON, PJ ;

LUJAN, LD ;

ROBINSON, NJ .

PLANT PHYSIOLOGY, 1989, 89 (02) :700-706

[2] TISSUE SULFHYDRYL GROUPS [J].

ELLMAN, GL .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) :70-77

[3] PHYTOCHELATINS - THE PRINCIPAL HEAVY-METAL COMPLEXING PEPTIDES OF HIGHER-PLANTS [J].

GRILL, E ;

WINNACKER, EL ;

ZENK, MH .

SCIENCE, 1985, 230 (4726) :674-676

[4] PHYTOCHELATINS, THE HEAVY-METAL-BINDING PEPTIDES OF PLANTS, ARE SYNTHESIZED FROM GLUTATHIONE BY A SPECIFIC GAMMA-GLUTAMYLCYSTEINE DIPEPTIDYL TRANSPEPTIDASE (PHYTOCHELATIN SYNTHASE) [J].

GRILL, E ;

LOFFLER, S ;

WINNACKER, EL ;

ZENK, MH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (18) :6838-6842

[5] PHYTOCHELATINS, A CLASS OF HEAVY-METAL-BINDING PEPTIDES FROM PLANTS, ARE FUNCTIONALLY ANALOGOUS TO METALLOTHIONEINS [J].

GRILL, E ;

WINNACKER, EL ;

ZENK, MH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (02) :439-443

[6] METALLOTHIONEIN [J].

HAMER, DH .

ANNUAL REVIEW OF BIOCHEMISTRY, 1986, 55 :913-951

[7] UNIQUE PROPERTIES OF CD-BINDING PEPTIDES INDUCED IN FISSION YEAST, SCHIZOSACCHAROMYCES-POMBE [J].

HAYASHI, Y ;

NAKAGAWA, CW ;

MURASUGI, A .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1986, 65 :13-19

[8] METALLOTHIONEINS - PROTEINS IN SEARCH OF FUNCTION [J].

KARIN, M .

CELL, 1985, 41 (01) :9-10

[9] OVEREXPRESSION OF METALLOTHIONEIN CONFERS RESISTANCE TO ANTICANCER DRUGS [J].

KELLEY, SL ;

BASU, A ;

TEICHER, BA ;

HACKER, MP ;

HAMER, DH ;

LAZO, JS .

SCIENCE, 1988, 241 (4874) :1813-1815

[10]

KOBAYASHI R, 1986, PROTEIN NUCLEIC ACID, V31, P991

← 1 2 →