INACTIVATION OF CHICKEN LIVER FATTY-ACID SYNTHETASE BY MALONYL COA

被引：3

作者：

KUMAR, S

SRINIVASAN, KR

机构：

[1] Department of Biochemistry, College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark

来源：

LIFE SCIENCES | 1979年 / 25卷 / 24-2期

关键词：

D O I：

10.1016/0024-3205(79)90194-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chicken liver fatty acid synthetase is inactivated by malonyl CoA. The rate and extent of inactivation depends upon the ratio of concentration of malonyl CoA to enzyme rather than the absolute concentrations. The rate of inactivation is enhanced by acetyl CoA but is slowed down by NADP+. Inactivation does not result in the dissociation of enzyme complex and is complete when 6-7 moles of malonyl group are covalently bound per mole of the enzyme. © 1979.

引用

页码：2035 / 2041

页数：7

共 6 条

[1] STABILIZATION AND PHYSICOCHEMICAL PROPERTIES OF FATTY ACID SYNTHETASE OF CHICKEN LIVER
HSU, RY
YUN, SL
[J]. BIOCHEMISTRY, 1970, 9 (02) : 239 - &
[2] EVIDENCE FOR AN ACTIVE SERINE IN EACH FATTY-ACID SYNTHETASE PEPTIDE
KOLATTUKUDY, PE
BUCKNER, JS
BEDORD, CJ
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 68 (02) : 379 - 386
[3] KUMAR S, 1971, J BIOL CHEM, V246, P7780
[4] KUMAR S, 1975, J BIOL CHEM, V250, P5150
[5] SMITH S, 1971, J BIOL CHEM, V246, P2537
[6] SRINIVASAN KR, 1976, J BIOL CHEM, V251, P5352

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