DISTRIBUTION OF HLA-DRB1, HLA-DQA1 AND HLA-DQB1 ALLELES AND DQA1-DQB1 GENOTYPES AMONG NORWEGIAN PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS

被引：144

作者：

RONNINGEN, KS

SPURKLAND, A

IWE, T

VARTDAL, F

THORSBY, E

机构：

[1] Institute of Transplantation Immunology, National Hospital, Oslo

来源：

TISSUE ANTIGENS | 1991年 / 37卷 / 03期

关键词：

DQ-ALPHA-BETA HETERODIMERS; DR4-SUBTYPES; HLA CLASS-II GENES; INSULIN-DEPENDENT DIABETES MELLITUS; SEQUENCE-SPECIFIC OLIGONUCLEOTIDES;

D O I：

10.1111/j.1399-0039.1991.tb01854.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have studied 87 unrelated Caucasian insulin-dependent diabetes mellitus (IDDM) patients and 181 healthy controls by oligotyping for 20 DRB1, eight DQA1 and 13 DQB1 alleles, and established their DR-DQ haplotypes and DQ genotypes. An increase of DRB1 alleles encoding DR4 was found among IDDM patients, but the distribution of DR4 subtypes did not differ among DR4-positive IDDM patients and controls. The frequency of certain DRB1-DQA1-DQB1 haplotypes and DQA1-DQB1 genotypes was significantly increased among IDDM patients. Taken together, the data suggest that IDDM is primarily associated with several (at least five) different DQ alpha-beta-heterodimers.

引用

页码：105 / 111

页数：7

共 35 条

[1]

APAIRICIO JMR, 1988, IMMUNOGENETICS, V228, P240

[2] HIGH-FREQUENCY OF ASPARTIC-ACID AT POSITION-57 OF HLA-DQ BETA-CHAIN IN JAPANESE IDDM PATIENTS AND NONDIABETIC SUBJECTS [J].