THE USE OF PARA-TOLUENESULFONIC ACID FOR REMOVAL OF THE N-TERT-BUTOXYCARBONYL PROTECTING GROUP IN SOLID-PHASE PEPTIDE-SYNTHESIS

被引：15

作者：

BRINKMAN, HR

LANDI, JJ

PATERSON, JB

STONE, PJ

机构：

[1] Contribution from the Chemical Development Department, Hoffmann-La Roche Inc, 340 Kingsland Street Nutley New Jersey

来源：

SYNTHETIC COMMUNICATIONS | 1991年 / 21卷 / 03期

关键词：

D O I：

10.1080/00397919108016770

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The usefulness of p-toluenesulfonic acid in THF/CH2Cl2 for Boc removal in solid phase peptide synthesis has been demonstrated through the syntheses of Leu-5 and Met-5 enkephalin acids.

引用

页码：459 / 465

页数：7

共 6 条

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[5]

SUZUKI K, 1978, CHEM PHARM BULL, V26, P2198

[6] SOLID-PHASE SYNTHESIS OF PROTECTED PEPTIDES VIA PHOTOLYTIC CLEAVAGE OF ALPHA-METHYLPHENACYL ESTER ANCHORING LINKAGE [J].

WANG, SS .

JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (20) :3258-3261

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