DIVERSITY AND SELECTION IN BABESIA-BOVIS AND THEIR IMPACT ON VACCINE USE

被引：16

作者：

DALRYMPLE, BP

机构：

[1] Brian Darlymple is at CSIRO, Division of Tropical Animal Production, Long Pocket Laboratories, Indooroopilly, QLD 4068, Private Bag No. 3, PO

来源：

PARASITOLOGY TODAY | 1992年 / 8卷 / 01期

关键词：

D O I：

10.1016/0169-4758(92)90306-M

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In the post few years the prospect of a recombinant vaccine effective against the cattle haemoparasite Babesia bovis has almost become a reality. However, in Australia, vaccination with live parasites has been practised since before the turn of the century and it has recently been proposed that selection of parasites resistant to immunity induced by the B. bovis line Ka (since 1979 the only component of the live attenuated vaccine) may have occurred. Brian Dalrymple examines the evidence for and against this proposal and discusses examples of strain diversity and variation and their effect on the long-term viability of defined attenuated and recombinant vaccines.

引用

页码：21 / 23

页数：3

共 28 条

[1] BABESIA-BOVIS - EVIDENCE FOR SELECTION OF SUBPOPULATIONS DURING ATTENUATION [J].

CARSON, CA ;

TIMMS, P ;

COWMAN, AF ;

STEWART, NP .

EXPERIMENTAL PARASITOLOGY, 1990, 70 (04) :404-410

[2] PROTEINASES IN THE LYSATE OF BOVINE ERYTHROCYTES INFECTED WITH BABESIA-BOVIS - INITIAL VACCINATION STUDIES [J].

COMMINS, MA ;

GOODGER, BV ;

WRIGHT, IG .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1985, 15 (05) :491-495

[3] DNA POLYMORPHISMS AND SUBPOPULATIONS IN BABESIA-BOVIS [J].

COWMAN, AF ;

TIMMS, P ;

KEMP, DJ .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1984, 11 (APR) :91-103

[4] GENES OF THE PROTOZOAN PARASITE BABESIA-BOVIS THAT REARRANGE TO PRODUCE RNA SPECIES WITH DIFFERENT SEQUENCES [J].

COWMAN, AF ;

BERNARD, O ;

STEWART, N ;

KEMP, DJ .

CELL, 1984, 37 (02) :653-660

[5] IN VITRO AGGLUTINATION OF BOVINE ERYTHROCYTES INFECTED WITH BABESIA ARGENTINA [J].

CURNOW, JA .

NATURE, 1968, 217 (5125) :267-&

[6] STUDIES ON ANTIGENIC CHANGES AND STRAIN DIFFERENCES IN BABESIA-ARGENTINA INFECTIONS [J].

CURNOW, JA .

AUSTRALIAN VETERINARY JOURNAL, 1973, 49 (06) :279-283

[7] CLONING AND CHARACTERIZATION OF THE RIBOSOMAL-RNA GENES AND FLANKING REGIONS FROM BABESIA-BOVIS - USE OF THE GENES AS STRAIN DISCRIMINATING PROBES [J].

DALRYMPLE, BP .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1990, 43 (01) :117-124

[8]

DEVOS AJ, IN PRESS TICK VECTOR

[9] NEW APPROACHES TO THE SEROTYPIC ANALYSIS OF THE EPIDEMIOLOGY OF PLASMODIUM-FALCIPARUM [J].

FORSYTH, KP ;

ANDERS, RF ;

KEMP, DJ ;

ALPERS, MP .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1988, 321 (1207) :485-493

[10] BABESIA-BOVIS - MOLECULAR AND BIOLOGICAL CHARACTERISTICS OF CLONED PARASITE LINES [J].

GILL, AC ;

COWMAN, AF ;

STEWART, NP ;

KEMP, DJ ;

TIMMS, P .

EXPERIMENTAL PARASITOLOGY, 1987, 63 (02) :180-188

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