B-CELL LYMPHOMA OF RECIPIENT ORIGIN 9 YEARS AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：8

作者：

TRIMBLE, MS

WAYE, JS

WALKER, IR

BRAIN, MC

LEBER, BF

机构：

[1] MCMASTER UNIV,MED CTR,DEPT MOLEC VIROL & IMMUNOL,RM 4417,1200 MAIN ST W,HAMILTON L8N 3Z5,ONTARIO,CANADA

[2] MCMASTER UNIV,MED CTR,DEPT MED,HAMILTON L8N 3Z5,ONTARIO,CANADA

[3] MCMASTER UNIV,MED CTR,DEPT PATHOL,HAMILTON L8N 3Z5,ONTARIO,CANADA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1993年 / 85卷 / 01期

关键词：

D O I：

10.1111/j.1365-2141.1993.tb08651.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 25-year-old woman developed an immunoblastic lymphoma 9 years after HLA-identical allogeneic bone marrow transplantation for T-cell acute lymphoblastic leukaemia in second remission. The B-cell origin of the second malignancy was confirmed by gene rearrangement studies. Despite continued donor engraftment, two separate genotypic analyses identified the lymphoma to be of recipient origin. This is the longest latency of a post-transplant recipient lymphoma yet reported and illustrates that recipient B-cells may survive the transplant conditioning regimen and undergo malignant transformation in the presence of donor haemopoiesis.

引用

页码：99 / 102

页数：4

共 16 条

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