RETINOIDS STIMULATE THE RELEASE OF SUPEROXIDE BY NEUTROPHILS AND CHANGE THEIR MORPHOLOGY

被引：31

作者：

BADWEY, JA

ROBINSON, JM

CURNUTTE, JT

KARNOVSKY, MJ

KARNOVSKY, ML

机构：

[1] HARVARD UNIV, SCH MED, DEPT BIOL CHEM, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA

[3] UNIV MICHIGAN, SCH MED, DEPT PEDIAT & COMMUNICABLE DIS, ANN ARBOR, MI 48109 USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 1986年 / 127卷 / 02期

关键词：

D O I：

10.1002/jcp.1041270206

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

All-trans-retinal stimulated the release of superoxide by human and guinea pig neutrophils 63 .+-. 14 SD and 53 .+-. 5 SD nmol of O2-/min/107 cells, respectively. Superoxide release by unstimulated cells was negligible. All-trans-retinal also induced morphological changes (i.e., evaginations) in these cells. Other retinoids were effective in instigating these phenomena. The similarities of these effects to those instigated by cis-unsaturated fatty acids (Badwey, J.A., et al., 1984, J. Biol. Chem., 259:7870-7877) are discussed in light of possible mechanisms.

引用

页码：223 / 228

页数：6

共 52 条

[1] FUSION OF ERYTHROCYTES BY FATTY-ACIDS, ESTERS, RETINOL AND ALPHA-TOCOPHEROL [J].