BURSTING RESPONSE TO CURRENT-EVOKED DEPOLARIZATION IN RAT CA1 PYRAMIDAL NEURONS IS CORRELATED WITH LUCIFER YELLOW-DYE COUPLING BUT NOT WITH THE PRESENCE OF CALBINDIN-D28K

被引:58
作者
BAIMBRIDGE, KG
PEET, MJ
MCLENNAN, H
CHURCH, J
机构
[1] Department of Physiology, University of British Columbia, Vancouver, British Columbia
关键词
DYE COUPLING; CA1 PYRAMIDAL NEURONS; LUCIFER YELLOW; ELECTROPHYSIOLOGY; RAT HIPPOCAMPUS;
D O I
10.1002/syn.890070404
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Calbindin-D28k (CaBP) immunohistochemistry has been combined with electrophysiological recording and Lucifer Yellow (LY) cell identification in the CA1 region of the rat hippocampal formation. CaBP is shown to be contained within a distinct sub-population of CA1 pyramidal cells which is equivalent to the superficial layer described by Lorente de No (1934). The neurogenesis of these CaBP-positive neurons occurs 1-2 days later than the CaBP-negative neurons in the deep pyramidal cell layer, as shown by H-3-thymidine autoradiography. No correlation could be found between the presence or absence of CaBP and the type of electrophysiological response to current-evoked depolarizing pulses. The latter could be separated into bursting or non-bursting types, and the bursting-type response was nearly always found to be associated with the presence of LY dye coupling. Furthermore, when dye coupling involved three neurons, a characteristic pattern was observed which may represent the coupling of phenotypically identical neurons into distinct functional units within the CA1 pyramidal cell layer. In this particular case the three neurons were all likely to be CaBP-positive.
引用
收藏
页码:269 / 277
页数:9
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