SYNTHESIS OF D-MYO-INOSITOL AND L-MYO-INOSITOL 1-PHOSPHOROTHIOATE, SUBSTRATES FOR INOSITOL MONOPHOSPHATASE

被引：41

作者：

BAKER, GR

BILLINGTON, DC

GANI, D

机构：

[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO9 5NH,HANTS,ENGLAND

[2] MERCK SHARP & DOHME LTD,NEUROSCI RES CTR,HARLOW CM20 2QR,ESSEX,ENGLAND

来源：

TETRAHEDRON | 1991年 / 47卷 / 23期

关键词：

D O I：

10.1016/S0040-4020(01)80912-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The D- and L- enantiomers of myo-inositol 1-phosphorothioate have been synthesized from 2,3,4,5,6-pentakis-O-benzyl myo-inositol in 6 steps, both compounds are substrates for inositol monophosphatase. D-glucopyranose 6-phosphorothioate did not serve as a substrate for the enzyme inositol synthase in an alternative synthesis of L-myo-inositol 1-phosphorothioate.

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页码：3895 / 3908

页数：14

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