COORDINATED REGULATION OF APOPTOSIS AND CELL-PROLIFERATION BY TRANSFORMING GROWTH FACTOR-BETA-1 IN CULTURED UTERINE EPITHELIAL-CELLS

被引：295

作者：

ROTELLO, RJ

LIEBERMAN, RC

PURCHIO, AF

GERSCHENSON, LE

机构：

[1] UNIV COLORADO,HLTH SCI CTR,SCH MED,DEPT PATHOL,DENVER,CO 80262

[2] ONCOGEN,SEATTLE,WA 98121

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 08期

关键词：

PROGRAMMED CELL DEATH; UTERUS;

D O I：

10.1073/pnas.88.8.3412

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor-beta-1 (TGF-beta-1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.

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页码：3412 / 3415

页数：4

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