INSIGHTS INTO DEUTERIUM-ISOTOPE EFFECTS ON THE METABOLISM OF STEROID-HORMONES AND FOREIGN COMPOUNDS BY CYTOCHROME-P-450 ENZYMES

被引：6

作者：

GILLETTE, JR

机构：

[1] Laboratory of Chemical Pharmacology National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda

来源：

LIFE SCIENCES | 1991年 / 49卷 / 01期

关键词：

D O I：

10.1016/0024-3205(91)90573-T

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

[No abstract available]

引用

页码：1 / 14

页数：14

共 9 条

[1]

CLELAND WW, 1982, CRC CR REV BIOCH MOL, V13, P385

[2] PARTITION ANALYSIS AND CONCEPT OF NET RATE CONSTANTS AS TOOLS IN ENZYME-KINETICS [J].

CLELAND, WW .

BIOCHEMISTRY, 1975, 14 (14) :3220-3224

[3] A SCHEMATIC METHOD OF DERIVING THE RATE LAWS FOR ENZYME-CATALYZED REACTIONS [J].

KING, EL ;

ALTMAN, C .

JOURNAL OF PHYSICAL CHEMISTRY, 1956, 60 (10) :1375-1378

[4] METABOLISM OF THE B-RING OF TESTOSTERONE BY THE RAT CYTOCHROME-P-450 SYSTEM [J].

KORZEKWA, K ;

NAGATA, K ;

TRAGER, WF ;

GILLETTE, JR .

DRUG METABOLISM REVIEWS, 1989, 20 (2-4) :535-539

[5]

KORZEKWA KR, 1990, DRUG METAB DISPOS, V18, P974

[6] DEUTERIUM-ISOTOPE EFFECTS ON TOLUENE METABOLISM - PRODUCT RELEASE AS A RATE-LIMITING STEP IN CYTOCHROME-P-450 CATALYSIS [J].

LING, KHJ ;

HANZLIK, RP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 160 (02) :844-849

[7]

NAGATA K, 1986, DRUG METAB DISPOS, V14, P559

[8]

Northrop D. B., 1977, ISOTOPE EFFECTS ENZY, P122

[9] MINIMAL KINETIC MECHANISM AND GENERAL EQUATION FOR DEUTERIUM-ISOTOPE EFFECTS ON ENZYMIC REACTIONS - UNCERTAINTY IN DETECTING A RATE-LIMITING STEP [J].

NORTHROP, DB .

BIOCHEMISTRY, 1981, 20 (14) :4056-4061

← 1 →