PIPERIDINE-MEDIATED SIDE PRODUCT FORMATION FOR ASP(OBU(T))-CONTAINING PEPTIDES

被引：66

作者：

DOLLING, R

BEYERMANN, M

HAENEL, J

KERNCHEN, F

KRAUSE, E

FRANKE, P

BRUDEL, M

BIENERT, M

机构：

[1] BIOTEZ BERLIN BUCH GMBH,D-13125 BERLIN,GERMANY

[2] INST MOLEC PHARMACOL,D-10315 BERLIN,GERMANY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 07期

关键词：

D O I：

10.1039/c39940000853

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A sequence- and conformation-dependent, unexpected high extent of aspartimide and piperidide formation is observed for the synthesis of Asp(OBu(t))-containing peptides using piperidine in the Fmoc-chemistry.

引用

页码：853 / 854

页数：2

共 8 条

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[4] JOUR WM, 1972, NATURE, V237, P82
[5] MARTINEZ J, 1978, INT J PEPT PROT RES, V12, P277
[6] FORMATION OF ASPARTIMIDE PEPTIDES IN ASP-GLY SEQUENCES
NICOLAS, E
PEDROSO, E
GIRALT, E
[J]. TETRAHEDRON LETTERS, 1989, 30 (04) : 497 - 500
[7] AMMONOLYSIS MEDIATED SIDE REACTIONS OF BETA-TERT-BUTYL ASPARTYL PEPTIDES
SCHON, I
RILL, A
[J]. COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1989, 54 (12) : 3360 - 3373
[8] UEKI M, 1990, PEPTIDE CHEMISTRY 1989, P23

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