DEVELOPMENT OF GLUCOSE-INTOLERANCE IN OBESE (FA FA) ZUCKER RATS

被引:24
作者
APWEILER, R
FREUND, P
机构
[1] BOEHRINGER MANNHEIM GERMANY,DEPT MED RES DIABET,SANDHOFERSTR 116,D-68305 MANNHEIM,GERMANY
[2] BOEHRINGER MANNHEIM GMBH,DEPT MED RES,W-6800 MANNHEIM 31,GERMANY
[3] ZENTRUM MOLEK BIOL HEIDELBERG,HEIDELBERG,GERMANY
关键词
INSULIN RESISTANCE; OBESITY; GLUCOSE INTOLERANCE; OGTT; FA FA RATS;
D O I
10.1055/s-2007-1002165
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Development of glucose intolerance in genetically obese (fa/fa) rats was investigated. Comparisons were made with lean (FA/?) control rats. Oral glucose tolerance tests were performed in 7-8 weeks, 9-10 weeks, 12-13 weeks and 16-17 weeks old rats. Irrespectively of age, the obese rats showed impaired glucose tolerance and insulin sensitivity compared with age-matched lean rats. While in FA/? rats only minor changes of glucose-stimulated insulin secretion and glucose tolerance were observed with progression of age, glucose intolerance in obese animals became more pronounced with aging. Obese rats older than 12-13 weeks showed no further progression of glucose intolerance. Glucose-stimulated insulin secretion increased with aging, but basal insulinemia was unaffected. Hence, we conclude that glucose intolerance and insulin resistance in genetically obese (fa/fa) rats is almost completely developed with approximately 12 weeks.
引用
收藏
页码:521 / 524
页数:4
相关论文
共 12 条
[1]  
BOWEN L, 1991, METABOLISM, V40, P125
[2]  
CRETTAZ M, 1981, Biochemical Society Transactions, V9, P524
[3]   INSULIN RESISTANCE IN SOLEUS MUSCLE FROM OBESE ZUCKER RATS - INVOLVEMENT OF SEVERAL DEFECTIVE SITES [J].
CRETTAZ, M ;
PRENTKI, M ;
ZANINETTI, D ;
JEANRENAUD, B .
BIOCHEMICAL JOURNAL, 1980, 186 (02) :525-534
[4]   OCULAR COMPLICATIONS IN THE OLD AND GLUCOSE-INTOLERANT GENETICALLY-OBESE (FA/FA) RAT [J].
DOSSO, A ;
RUNGGERBRANDLE, E ;
ROHNERJEANRENAUD, F ;
IONESCU, E ;
GUILLAUMEGENTIL, C ;
JEANRENAUD, B ;
LEUENBERGER, PM .
DIABETOLOGIA, 1990, 33 (03) :137-144
[5]   REDUCTION OF INSULIN RESISTANCE IN OBESE AND OR DIABETIC ANIMALS BY 5-[4-(1-METHYLCYCLOHEXYLMETHOXY)BENZYL]-THIAZOLIDINE-2,4-DIONE (ADD-3878, U-63,287, CIGLITAZONE), A NEW ANTI-DIABETIC AGENT [J].
FUJITA, T ;
SUGIYAMA, Y ;
TAKETOMI, S ;
SOHDA, T ;
KAWAMATSU, Y ;
IWATSUKA, H ;
SUZUOKI, Z .
DIABETES, 1983, 32 (09) :804-810
[6]   CHARACTERIZATION OF NEW ORAL ANTIDIABETIC AGENT CS-045 - STUDIES IN KK AND OB OB MICE AND ZUCKER FATTY RATS [J].
FUJIWARA, T ;
YOSHIOKA, S ;
YOSHIOKA, T ;
USHIYAMA, I ;
HORIKOSHI, H .
DIABETES, 1988, 37 (11) :1549-1558
[7]  
FURNSINN C, 1991, ENDOCRINOLOGY, V128, P1093, DOI 10.1210/endo-128-2-1093
[8]   ABNORMAL ORAL GLUCOSE-TOLERANCE IN GENETICALLY-OBESE (FA/FA) RATS [J].
IONESCU, E ;
SAUTER, JF ;
JEANRENAUD, B .
AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (05) :E500-E506
[9]   BENEFICIAL EFFECT OF INTRAVENOUS BOLUS OF CORTICOTROPIN-RELEASING FACTOR ON GLUCOSE-INTOLERANCE OF GENETICALLY-OBESE (FA/FA) RATS [J].
ROHNERJEANRENAUD, F ;
JEANRENAUD, B .
DIABETES, 1992, 41 (04) :493-498
[10]  
SCHMIDT FH, 1973, 3 INT DON S DIAB MEL, P567