TRIENEDIOLATES OF HEXADIENOIC ACIDS IN SYNTHESIS - SYNTHESIS OF RETINOIC AND NOR-RETINOIC ACIDS

被引：7

作者：

AURELL, MJ ^{[1
]}

CARNE, I ^{[1
]}

CLAR, JE ^{[1
]}

GIL, S ^{[1
]}

MESTRES, R ^{[1
]}

PARRA, M ^{[1
]}

TORTAJADA, A ^{[1
]}

机构：

[1] UNIV VALENCIA,DEPT QUIM ORGAN,VALENCIA,SPAIN

来源：

TETRAHEDRON | 1993年 / 49卷 / 27期

关键词：

D O I：

10.1016/S0040-4020(01)87193-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Double deprotonation of either (E,E)-3-methyl-2,4-hexadienoic acid 2. or 4,6-dimethyldihydro-2-pyrone 3 generates apparently the same lithium trienediolate, which affords omega-hydroxy acids 9 on reaction with ketones 7. Hydroxy acids 9 arc easily dehydrated to octatrienoic acids 5. which are structurally related to retinoic acid. Similarly, sorbic acid 1 leads to nor-retinoic acid analogs 6.

引用

页码：6089 / 6100

页数：12

共 15 条

[1] POLYENOLATES OF UNSATURATED CARBOXYLIC-ACIDS IN SYNTHESIS - A STRAIGHTFORWARD SYNTHESIS OF RETINOIC ACIDS [J].