ESSENTIAL FATTY-ACID PREPARATION (SR-3) REHABILITATES LEARNING-DEFICITS INDUCED BY AF64A AND 5,7-DHT

被引：20

作者：

YEHUDA, S

CARRASO, RL

MOSTOFSKY, DI

机构：

[1] HILLEL JAFFE HOSP,DEPT NEUROL,HADERA,ISRAEL

[2] BOSTON UNIV,DEPT PSYCHOL,BOSTON,MA 02215

来源：

NEUROREPORT | 1995年 / 6卷 / 03期

关键词：

FATTY ACIDS; LINOLEIC ACID; ALPHA-LINOLENIC ACID; AF64A; 5,7-DHT; LEARNING; MORRIS WATER MAZE;

D O I：

10.1097/00001756-199502000-00026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE purpose of this study was to examine the possible effects of a novvel mixture of fatty acids, SR-3 (a specific ratio between alpha-linolenic and linoleic acids) on learning deficits induced by cholinergic (AF64A) and serotonergic (5,7-DHT) neurotoxins in rats. I.c.v. AF64A and 4th ventricle administration of 5,7-DHT induce severe learning deficit using the Morris Water Tank. Three weeks of treatment with SR-3 rehabilitated the learning capacity of rats. However, learning deficits induced by a lesion in area postrema was not rehabilitated by SR-3. The mode of action of SR-3 is unknown. We propose that this combination of free fatty acids modulates the composition of neuronal membrane lipids and allows communication.

引用

页码：511 / 515

页数：5

共 20 条

[1] THE USE OF THE MORRIS WATER MAZE IN THE STUDY OF MEMORY AND LEARNING [J].