IMPAIRMENT OF MOTOR COORDINATION, PURKINJE-CELL SYNAPSE FORMATION, AND CEREBELLAR LONG-TERM DEPRESSION IN GLUR-DELTA-2 MUTANT MICE

被引：488

作者：

KASHIWABUCHI, N

IKEDA, K

ARAKI, K

HIRANO, T

SHIBUKI, K

TAKAYAMA, C

INOUE, Y

KUTSUWADA, T

YAGI, T

KANG, Y

AIZAWA, S

MISHINA, M

机构：

[1] NIIGATA UNIV,BRAIN RES INST,DEPT PHYSIOL,NIIGATA 951,JAPAN

[2] KYOTO UNIV,FAC MED,DEPT PHYSIOL,KYOTO 606,JAPAN

[3] HOKKAIDO UNIV,SCH MED,DEPT ANAT,SAPPORO,HOKKAIDO 060,JAPAN

[4] INST PHYS & CHEM RES,TSUKUBA LIFE SCI CTR,MOLEC ONCOL LAB,IBARAKI,OSAKA 305,JAPAN

[5] UNIV TOKYO,FAC MED,DEPT PHARMACOL,TOKYO 113,JAPAN

来源：

CELL | 1995年 / 81卷 / 02期

关键词：

D O I：

10.1016/0092-8674(95)90334-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Of the six glutamate receptor (GluR) channel subunit families identified by molecular cloning, five have been shown to constitute either the AMPA, kainate, or NMDA receptor channel, whereas the function of the delta subunit family remains unknown. The selective localization of the delta 2 subunit or the GluR delta subfamily in cerebellar Purkinje Cells prompted us to examine its possible physiological roles by the gene targeting technique. Analyses of the GluR delta 2 mutant mice reveal that the delta 2 subunit plays important roles in motor coordination, formation of parallel fiber-Purkinje cell synapses and climbing fiber-Purkinje cell synapses, and long-term depression of parallel fiber-Purkinje cell synaptic transmission. These! results suggest a close relationship between synaptic plasticity and synapse formation in the cerebellum.

引用

页码：245 / 252

页数：8

共 36 条

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