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SEROTONERGIC STIMULATION OF PROLACTIN SECRETION IS INHIBITED BY VASOACTIVE-INTESTINAL-PEPTIDE IMMUNONEUTRALIZATION IN THE TURKEY

被引：26
作者：
ELHALAWANI, ME [1 ]
YOUNGREN, OM [1 ]
ROZENBOIM, I [1 ]
PITTS, GR [1 ]
SILSBY, JL [1 ]
PHILLIPS, RE [1 ]
机构：
[1] UNIV MINNESOTA, DEPT ECOL EVOLUT & BEHAV, ST PAUL, MN 55108 USA
来源：
GENERAL AND COMPARATIVE ENDOCRINOLOGY | 1995年 / 99卷 / 01期
关键词：
D O I：
10.1006/gcen.1995.1086
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The neuronal mechanisms that govern prolactin (PRL) secretion in the turkey appear to involve monoaminergic systems. Considerable evidence indicates that serotonin (5-HT), acting centrally, is a potent stimulator of PRL secretion. This study, using birds actively immunized against VIP, tests the hypothesis that 5-HT stimulates PRL secretion by releasing vasoactive intestinal peptide (VIP). Nonimmunized turkeys were injected ip with saline, quipazine (5-HT agonist; 5 mg/kg), methysergide (5-HT antagonist; 8 mg/kg), or methysergide plus quipazine, and VIP-immunized birds were injected with saline or quipazine. Quipazine increased plasma PRL revels from 26.8 +/- 7.1 ng/ml at Time 0 to a peak value of 148.1 +/- 31.4 ng/ml 2 hr after injection. Pretreatment with methysergide or VIP-immunoneutralization abolished the PRL response to quipazine. Intraventricular infusion of 5-HT (1 nmol/min) caused plasma PRL to rise from a baseline of 16.3 +/- 2.6 ng/ml to 85.2 +/- 14.3 ng/ml after 30 min in nonimmunized control birds. Serotonin infusion did not induce PRL secretion in the VIP-immunized birds. These findings suggest that serotonergic stimulation of PRL secretion in the female turkey requires a functional VIPergic system. (C) 1995 Academic Press, Inc.
引用
收藏
页码：69 / 74
页数：6
相关论文
共 30 条
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