CYTOTOXICITIES OF GINSENG SAPONINS AND THEIR DEGRADATION PRODUCTS AGAINST SOME CANCER CELL-LINES

被引：50

作者：

BAEK, NI

KIM, DS

LEE, YH

PARK, JD

LEE, CB

KIM, SI

机构：

[1] KOREA GINSENG & TOBACCO RES INST,TAEJON 305345,SOUTH KOREA

[2] CHUNGNAM NATL UNIV,DEPT BIOCHEM,TAEJON 305345,SOUTH KOREA

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1995年 / 18卷 / 03期

关键词：

PANAX GINSENG; CYTOTOXICITY; GINSENOSIDES; PROSAPOGENINS; SAPOGENINS; STRUCTURE-CYTOTOXICITY RELATIONSHIP;

D O I：

10.1007/BF02979189

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to elucidate the cytotoxicity/-structure correlation of ginseng-derived components, several prosapogenins and sapogenins were prepared from Korean red ginseng (Panax ginseng) saponins by acid hydrolysis or alkaline cleveage, and their chemical structures were identified by a combination of spectral and physical methods. Some of these degradation products showed the cytotoxic activities against various cancer cell lines, A549, SK-OV-3, SK-Mel-2, P388, L1210 and K562. The significant difference in cytotoxicity between stereoisomers was not found and the activity was inversely proportional to the number of sugars linked to sapogenins. Diol-type prosapogenins and sapogenins showed higher cytotoxicity than triol-type ones.

引用

页码：164 / 168

页数：5

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