EFFECT OF PRECURSORS, PRODUCTS, AND PRODUCT ANALOGS OF PROSTAGLANDIN CYCLOOXYGENASE UPON IRIS SPHINCTER MUSCLE

被引：48

作者：

CRAWFORD, CG ^{[1
]}

VANALPHEN, GWHM ^{[1
]}

COOK, HW ^{[1
]}

LANDS, WEM ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT OPHTHALMOL,ANN ARBOR,MI 48109

来源：

LIFE SCIENCES | 1978年 / 23卷 / 12期

基金：

美国国家科学基金会; 英国医学研究理事会;

关键词：

D O I：

10.1016/0024-3205(78)90503-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Contractions of isolated iris sphincter muscles were measured in response to several free fatty acids, hydroperoxy and hydroxy derivatives of 20:3(n-3), 20:3(n-6) and 20:4, PGH2, and the epoxymethano methano analogs of PGH2. The free acids of prostaglandin precursors elicited comparatively strong contractions, hydroperoxy and hydroxy acids gave intermediate and nonspecific response whereas nonprostaglandin precursor acids elicited little response. PGH2 was 100 to 1000 times more effective than arachidonic acid or the epoxymethano analogs. The latter compounds inhibited the production of contractions by PGH2. These results allow an interpretation that the iris sphincter muscle contains an active thromboxane synthase and receptors for endoperoxide and thromboxane that initiate contraction. © 1978.

引用

页码：1255 / 1262

页数：8

共 32 条

[1] INHIBITION OF OCULAR EFFECTS OF SODIUM ARACHIDONATE BY ANTIINFLAMMATORY COMPOUNDS [J].