INTERACTION OF VINBLASTINE ANALOGS WITH TUBULIN

被引：57

作者：

ZAVALA, F

GUENARD, D

POTIER, P

机构：

[1] Institut de Chimie des Substances Naturelles du CNRS, Gif/Yvette

来源：

EXPERIENTIA | 1978年 / 34卷 / 11期

关键词：

D O I：

10.1007/BF01932374

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Studies of the interaction between vinblastine-like alkaloids and their receptor, i.e. tubulin, are reported. They shed some light on the structure-activity relationships in this medicinally important series: the configurations at C14′ and C16′ as well as the presence of the methoxycarbonyl group on C16′ seem to play an essential role in the determination of biological activity. © 1978 Birkhäuser Verlag.

引用

页码：1497 / 1499

页数：3

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