DRUG TARGETING - ANTI-HSV-1 ACTIVITY OF MANNOSYLATED POLYMER-BOUND 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE

被引：32

作者：

MIDOUX, P

NEGRE, E

ROCHE, AC

MAYER, R

MONSIGNY, M

BALZARINI, J

DECLERCQ, E

MAYER, E

GHAFFAR, A

GANGEMI, JD

机构：

[1] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

[2] UNIV S CAROLINA,SCH MED,DEPT MICROBIOL & IMMUNOL,COLUMBIA,SC 29208

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 167卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)90628-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antiviral drug, 9-(2-phosphonylmethoxyethyl) adenine (PMEA) was linked to a synthetic and neutral polymer bearing mannosyl residues to allow its internalization by macrophages via membrane lectins. PMEA bound to the mannosylated polymer was more efficient in vitro than free PMEA in preventing lysis of human macrophages by herpes virus. © 1990.

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页码：1044 / 1049

页数：6

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