THE SYNTENIC RELATIONSHIP OF PROXIMAL MOUSE CHROMOSOME-7 AND THE MYOTONIC-DYSTROPHY GENE REGION ON HUMAN CHROMOSOME-19Q

被引：36

作者：

SAUNDERS, AM

SELDIN, MF

机构：

[1] Department of Medicine, Duke University Medical Center, Durham

来源：

GENOMICS | 1990年 / 6卷 / 02期

关键词：

D O I：

10.1016/0888-7543(90)90573-D

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The syntenic relationship of the myotonic dystrophy (DM) gene region on human chromosome 19q and proximal mouse chromosome 7 was examined using an interspecific backcross between C3H/HeJ- gld gld mice and Mus spretus. Segregation analyses were used to order homologs of nine human loci linked were the DM gene. Their order from the centromere was Prkcg, [Apoe, Atpa-2, Ckmm, D19S19h, Ercc-2], Cyp2b, Mag. Lhb. Two other murine loci, D7Rp2 and Ngfg, were also positioned within this interval. Homologs for five human chromosome 11 and 15 loci (Calc, Fes, Hras-1, Igflr, Tyr) were localized within an 18-cM span telomeric to Lhb. Comparison of the gene orders indicates an inversion extending from Prkcg through the interval between Mag and Lhb. This study establishes a detailed map of proximal mouse chromosome 7 that will be useful in identifying and determining whether new human chromosome 19 probes are linked to the DM region. © 1990.

引用

页码：324 / 332

页数：9

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