INTRANUCLEAR RODLETS IN UNDIFFERENTIATED CARCINOMAS OF SALIVARY-GLANDS IN STRAIN A MICE IN A STUDY INVOLVING A TOBACCO SPECIFIC NITROSAMINE, N-NITROSONORNICOTINE

被引：3

作者：

HIROTA, N

机构：

[1] Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla

来源：

CANCER LETTERS | 1979年 / 6卷 / 06期

关键词：

D O I：

10.1016/S0304-3835(79)80095-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Undifferentiated carcinomas of the salivary glands were found in 2 of 44 (4.5%) strain A mice injected intraperitoneally with a tobacco specific nitrosamine, N-nitrosonornicotine (NNN). The presence of intranuclear rodlets (INR) in the salivary carcinomas provided the first demonstration of such structures in a non-neuronal tumor in mice. Two types of rodlets were exhibited; one was composed of fibrillar filaments arranged in bundles, and the other was much thicker, branching in form. These INR appeared to be closely associated with nuclear chromatin or nucleoli. © 1979 Elsevier/North-Holland Scientific Publishers Ltd., All rights reserved.

引用

页码：365 / 369

页数：5

共 15 条

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