HIV EXCRETION PATTERNS AND SPECIFIC ANTIBODY-RESPONSES IN BODY-FLUIDS

被引：61

作者：

OSHEA, S

CORDERY, M

BARRETT, WY

RICHMAN, DD

BRADBEER, C

BANATVALA, JE

机构：

[1] UNIV CALIF SAN DIEGO, VET ADM MED CTR, DEPT INFECT DIS, LA JOLLA, CA 92093 USA

[2] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP, DEPT GENITOURINARY MED, LONDON SE1 7EH, ENGLAND

来源：

JOURNAL OF MEDICAL VIROLOGY | 1990年 / 31卷 / 04期

关键词：

antibodies; HIV nucleic acid; PCR;

D O I：

10.1002/jmv.1890310409

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV excretion patterns and specific antibody responses were evaluated in blood, semen, female genital secretions, saliva, and crevicular fluid. Samples were examined for infectious virus, viral antigens, viral nucleic acid, HIV specific IgG, IgA, anti‐nef, and anti‐p24. Viral load in peripheral blood appeared to increase with disease progression. The proportion of patients with antibody responses specific for nef and p24 was also lower among patients with more advanced disease. Infectious virus and viral antigens were detected infrequently and at lower levels in body fluids than in blood, which may reflect the presence of local antibodies. HIV nucleic acid was detected in some semen and saliva samples in the absence of infectious virus. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：291 / 296

页数：6

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